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D-3263 hydrochloride

CAS No. 1008763-54-9

D-3263 hydrochloride ( D3263 HCl salt; EC D-3263 HCl )

Catalog No. M26136 CAS No. 1008763-54-9

D-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    D-3263 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    D-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.
  • Description
    D-3263 hydrochloride is enteric-coated, orally bioavailable (transient receptor potential melatonin member 8) TRPM8 agonist.(In Vitro):D-3263 hydrochloride binds and activates TRPM8, which may lead to increased entry of calcium and sodium; destruction of calcium and sodium homeostasis; induction of cell death in tumor cells expressing TRPM8. D-3263 hydrochloride may reduce the level of dihydrotestosterone (DHT), which may contribute to its inhibitory effect on prostate cancer and BPH.
  • Synonyms
    D3263 HCl salt; EC D-3263 HCl
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GnRHR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1008763-54-9
  • Formula Weight
    410.0
  • Molecular Formula
    C21H32ClN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Cl.COc1ccc2n(C(=O)[C@@H]3C[C@H](C)CC[C@H]3C(C)C)c(=O)n(CCN)c2c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Ezzati M, Carr BR (2015).?"Elagolix, a novel, orally bioavailable GnRH antagonist under investigation for the treatment of endometriosis-related pain".?Womens Health (Lond).?11?(1): 19–28.
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